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Melatonin Info

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Melatonin Information

Melatonin is a hormone made by the pineal gland camera, a small gland in the brain. Melatonin helps control your sleep and wake cycles. Very small amounts of it are found in foods such as meats, grains, fruits, and vegetables. You can also buy it as a supplement. Melatonin is also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants, and microbes. In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions. Melatonin is a hormone produced by the pinealocytes in the pineal gland (epiphysis)  a part of the midbrain of serotonin and controls the day night rhythm of the human body. Chemically, it is an alkaloid tryptamine structure. Many biological effects of melatonin are produced through activation of melatonin receptors, while others are due to its role as a pervasive and powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA. People use melatonin to adjust the body’s internal clock. It is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping blind people establish a day and night cycle.
Melatonin Animals
Many animals use the variation in duration of melatonin production each day as a seasonal clock. In animals including humans the profile of melatonin synthesis and secretion is affected by the variable duration of night in summer as compared to winter. In mammals, melatonin is biosynthesized in four enzymatic steps from the essential dietary amino acid tryptophan, with serotonin produced at the third step. In animal melatonin has been demonstrated to prevent the damage to DNA by some carcinogens, stopping the mechanism by which they cause cancer, In mammals, the role of melatonin in the control of seasonality is well documented, The only natural source of melatonin that can be used in medication comes from the pineal glands of these animals, Melatonin tended to enhance the reaction of younger animals to LPS suppressed the inflammatory response of older mice, Animals that are awake during the day and asleep at night also produce melatonin to regulate this cycle. 
Melatonin and Antioxidant
Besides its function as synchronizer of the biological clock, melatonin also exerts a powerful antioxidant activity. Melatonin is an antioxidant that can easily cross cell membranes. The discovery of melatonin as an antioxidant was made in 1993. In many less complex life forms, this is its only known function. Because melatonin acts as an antioxidant, it is being studied as a possible treatment for cancer. Melatonin is a direct scavenger and NO. Unlike other antioxidants, melatonin does not undergo redox cycling, the ability of a molecule to undergo reduction and oxidation repeatedly. Redox cycling may allow other antioxidants to act as pro oxidants, counterintuitively promoting free radical formation. The antioxidant effects of melatonin may enhance the effectiveness of chemotherapy drugs and reduce their side effects. Melatonin, on the other hand, once oxidized, cannot be reduced to its former state because it forms several stable end-products upon reacting with free radicals. Recent research indicates that the first metabolite of melatonin in the melatonin antioxidant pathway. This capacity to absorb free radicals extends at least to the quaternary metabolites of melatonin. The research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death. Melatonin's antioxidant activity may reduce damage caused by some types of Parkinson's disease, may play a role in preventing cardiac arrhythmia and may increase longevity.
Melatonin and Aging
Research has supported the anti aging properties of melatonin. There are claims that melatonin levels decrease as we age. These claims are based on the observation that older people need less sleep. Younger children hit their peak melatonin production at night, and some researchers believe that the level of melatonin peaks earlier as we get older. If you're not getting enough sleep, there's a good chance your melatonin production is not up to par either, and this could have far impacts on your health, even accelerating the aging process of your brain. This may explain why older adults go to bed earlier, wake up earlier, and have more sleep problems than children do. In a new study, artificially aged mice treated with melatonin had reduced oxidative stress and markers of cerebral aging. Some studies have shown that melatonin plays a crucial part in the aging process and that it may act as an anti-aging agent when taken by older adults. According to the researchers, the pineal gland and melatonin are involved in the processes of both aging and age related diseases. melatonin may reverse this change in gene expression thus making the genes of elderly people similar to those of younger people. Melatonin has potential utility both in slowing normal brain aging and in treatment of neurodegenerative conditions. One study conducted by researchers of the University of Granada’s Institute of Biotechnology found that consuming melatonin may neutralize oxidative damage, and delay the neurodegenerative process of aging. There evidence that melatonin decreases the aging rate, improves skin health. When small amounts of melatonin were administered to lab mice, it reduced the oxidative damage caused by aging and delayed the inflammatory process, which in turn increased the longevity of the mice. melatonin is rapidly emerging as a powerful agent in the fight against brain aging, and neurologic deterioration.
Melatonin memory and Alzheimer
Melatonin receptors appear to be important in mechanisms of learning and memory in mice, and melatonin can alter electrophysiological processes associated with memory, such as long term potentiation, several clinical studies have found signs of physical and mental benefits in sufferers of Alzheimer's resulting from both treatments. Those Alzheimer's patients with this specific affliction often show heightened afternoon agitation, called sundowning, which has been shown in many studies to be effectively treated with melatonin supplements in the evening, With the approval of melatonin as a medication in the European Union in 2007, clinical testing on this molecule has been increasing, melatonin is also a powerful brain antioxidant. Studies in rats suggest that melatonin may be effective for treating Alzheimer's disease. These same neurofibrillary tangles can be found in the hypothalamus in patients with Alzheimer's, adversely affecting their bodies' production of melatonin. Take the hormone melatonin, for example, which is made primarily in the pineal gland, The recent clinical trials showing that melatonin helps prevent Alzheimer's disease in high risk patients. Melatonin has been shown to prevent the hyperphosphorylation of the tau protein in rats. Hyperphosphorylation of tau protein can also result in the formation of neurofibrillary tangles, studies have shown that melatonin is implicated in modulating learning and memory processing. Melatonin also inhibits the aggregation of the amyloid beta protein into neurotoxic microaggregates that, it seems, underlie the neurotoxicity of this protein, causing death of neurons and formation of neurofibrillary tangles, neuropathological landmark of Alzheimer's disease, melatonin improve neuronal and cognitive impairment in a rat model of Alzheimer' disease The first published evidence that melatonin may be useful in Alzheimer's disease was the demonstration that this neurohormone prevents neuronal death caused by exposure to the amyloid beta protein, a neurotoxic substance that accumulates in the brains of patients with the disorder, Human prospective studies have also shown that Alzheimer's patients tend to have lower melatonin levels.
Melatonin and Jet Lag
Jet lag is caused by flying in an airplane and crossing one or more time zones, which can disrupt the body's sleep and wake cycle, melatonin has been widely studied, and it's now a commonly accepted part of effective jet lag treatment. Melatonin is a hormone a serotonin derivative, produced in the pineal gland of the brain. You can try taking melatonin to reduce the symptoms of jet lag, you should take melatonin in the evening, Those taking melatonin slept for longer than those  participants taking the placebo. Taking melatonin after dark the day you travel and after dark for a few days after arriving at your destination, Avoid alcohol when taking melatonin, Taking melatonin in the evening a few days before you fly if flying, melatonin's effect on inducing sleep and modifying the biological clock points to the conclusion that it is indeed effective towards neutralizing jet lag.Melatonin role in human health is far more profound than was once suspected. We now know that melatonin has remarkable properties to function as an antioxidant and as a modulator of the immune system. As an antioxidant, it works on several levels, Passengers on both flights took either melatonin or the placebo two to three days before their flight, The brain’s receptors for melatonin are signaled by light that enters through the eyes.Receptors for melatonin molecule are located throughout the body, it’s important to understand how the body’s circadian rhythm works with melatonin and avoiding jet lag, To fully understand melatonin’s role in circadian rhythm.
Melatonin History
Melatonin is related to the mechanism by which some amphibians and reptiles change the color of their skin and, indeed, it was in this connection the substance first was discovered, The history of Melatonin begins with the history of the pineal gland, In the 16th century. In 1958 dermatology professor Aaron B. Lerner and colleagues at Yale University, in the hope that a substance from the pineal might be useful in treating skin diseases, isolated the hormone from bovine pineal gland extracts and named it melatonin. With these recent careful and precise observations in blind persons, the true potential of melatonin is becoming evident, and the importance of the timing of treatment is becoming clear. Our 24-hour society, with its chaotic time cues and lack of natural light, may yet reap substantial benefits, In 1995 it was discovered that high levels of Melatonin could be found in carrots, tomatoes, nuts. As early as 1917, Carey Pratt McCord and Floyd P. Allen discovered that feeding extract of the pineal glands of cows lightened tadpole skin by contracting the dark epidermal melanophores, Melatonin was first isolated from pineal glands of cattle by the dermatologist Aaron Lerner at Yale University in 1958. Around the same time, the hormone got a lot of press as a possible treatment for many illnesses. The New England Journal of Medicine editorialized in 2000: The hype and the claims of the called miraculous powers of melatonin several years ago did a great disservice to a scientific field of real importance to human health. The discovery that melatonin is an antioxidant was made in 1993. The first patent for its use as a low dose sleep aid was granted to Richard Wurtman at MIT in 1995. In the mid-70s Lynch et al. demonstrated that the production of melatonin exhibits a circadian rhythm in human pineal glands, Melatonin appears to be the primary sleep regulating hormone of the body, In 1984, a study was conducted in which people were given various dosages of Melatonin before they went to bed, and it was found that Melatonin made people sleepy,Melatonin’s responsiveness to light in lower animals was discovered.
The Health Benefits of Melatonin
Melatonin is a product of synthesis exactly identical with the hormone that is produced in the pineal gland and which brings substantial benefits, Taking melatonin will help people who suffer from insomnia to be able to fall asleep sooner. For insomnia melatonin is the best and safest sleeping pills on the market. It's effective in just one hour with up to 90% of the active ingredient. Sleep, which is induced by melatonin is deeper, more relaxing and healthier than that of ordinary sleeping pills. The melatonin users always wakes up fresh and rested. melatonin at night will help to reduce the symptoms of jet lag, Melatonin is especially effective for jet lag (time shift) and complaints related to the change of the day-night rhythm in combination, especially with shift work, The same applies to the seasonal mood disorders in people whose biorhythms are difficult to adapt to the changing conditions of the seasons, Melatonin neutralizes the effects of stress and reduces the gradual decline of the immune system that accompanies it. Melatonin is the only antioxidant that can directly penetrate into the brain, since both fat and water soluble, Many studies show that melatonin can protect against cancer and the dangers of toxic chemotherapy, It provides the functionality of the thymus restores and increases the number of lymphocytes. Research also shows that supplementing with melatonin can reduce high blood pressure, colds can cope better and can stop the effects of the aging process and reduce overall.
• Melatonin Helps Regulate Sleep Cycle
• Melatonin Resets Sleep Wake Cycle
• Melatonin Stop or slow the aging
• Melatonin Provides natural support for healthy sleep.
• Melatonin Helps circadian rhythyms normalize after jet lag.
• Melatonin Has a variety of antioxidant activitie
Notes on melatonin ingestion
Melatonin supplements should be taken only in case of permanent insomnia and under the guidance of a specialist, Melatonin is not so much a 'sleep enhancer' as it is an anti-insomnia supplement, Self is not very reasonable and in the worst case, even risky. Individual reports describe a positive effect of melatonin in cluster headache Prophylaxe, Vor of prescribing and the administration of melatonin, melatonin being a powerful anti-oxidant, the endogenous melatonin rhythm should be reviewed. This can be done by the hospital blood collection, whereas here the effort and costs are considerable, especially since melatonin is not determined routinely in all laboratories. Alternatively, the melatonin levels of non invasive can be determined from the saliva, as are present in the saliva approximately one third of the values in the blood, Such a saliva test for melatonin can also be done at home. Usage of melatonin is not associated with negative feedback, The costs assumed for the determination of melatonin and the costs of melatonin supplements are currently only a few funds, In any case, it is reasonable to ask the cash advance, if you do not want to bear the costs themselves, Some effects of melatonin were apparent 5 hours after ingestion when the increase in body temperature subsided.
Melatonin and Gallbladder stones
Melatonin is produced primarily in darkness and inhibited by light, Melatonin presence in the gallbladder has many protective properties, Melatonin is naturally produced in the Body Melatonin preventing oxidative stress, and increasing the mobility of gallstones from the gallbladder, Melatonin was used to treat periodic limb movement disorder lack of melatonin could significantly contribute to gallbladder stones, The melatonin study analyzes the time on Melatonin when people have Gallstones, gender, age of these people, Melatonin also decreases the amount of cholesterol produced in the gallbladder by regulating the cholesterol Melatonin is available as a prolonged-release that passes through the intestinal . In guinea pigs, melatonin administration restored normal function by reducing inflammation after induced cholecystitis, whether administered before or after onset of inflammation, Melatonin has active ingredients of melatonin. Melatonin used in insomnia, sleep disorder, Melatonin treatment prevented qualitative changes in gallbladder neurotransmission Concentration of melatonin in the bile is 2 or 3 times higher than the otherwise very low daytime melatonin levels in the blood across many diurnal mammals, including humans, Melatonin include pain, fatigue, nausea, dizziness, insomnia, melatonin efficacious against different diseases where oxidative stress.
Melatonin Light dependence
Melatonin the light of night is secreted from the pineal gland principally at night, Production of melatonin by the pineal gland is inhibited by light to the retina and permitted by darkness. Its onset each evening is called the dim light melatonin onset, It is principally blue light, around 460 to 480 nm, that suppresses melatonin proportional to the light intensity and length of exposure, Until recent history, humans in temperate climates were exposed to few hours of daylight in the winter; their fires gave predominantly yellow light, Human melatonin suppression by light is intensity dependent, The incandescent light bulb widely used in the twentieth century produced relatively little blue light, In higher animals and humans, melatonin is produced by pinealocytes in the pineal gland, Wearing glasses that block blue light in the hours before bedtime may decrease melatonin loss, In animal studies, melatonin provided protection against gram negative septic shock, prevented stress induced immunodepression, showed that light containing only wavelengths greater than 530 nm does not suppress melatonin in bright light conditions, Many animals use the variation in duration and quantity of melatonin production in each day as a seasonal clock, Suppression of night time melatonin production was used as the light dependent response, melatonin seems to regulate the tone of cerebral arteries, Use of blue blocking goggles the last hours before bedtime has also been advised for people who need to adjust to an earlier bedtime, as melatonin promotes sleepiness, Products containing melatonin have been available as a dietary supplement, When used several hours before sleep according to the phase response curve for melatonin in humans
Melatonin and menopause
Melatonin affects the timing of Freisetung with the female hormones that control the menstrual cycle, Melatonin supports the positive effects of sleep in women during menopause. Also used by postmenopausal women, melatonin to regulate sleep should do so only briefly, since long term effects are not yet known, insomnia is one of the more frustrating and distressing symptoms that women experience during menopause, melatonin has long been used as a temporary remedy to help establish a normal sleep pattern, women suffering from insomnia if melatonin turns out to be not only good for regulating sleep, Melatonin helps you to fall asleep at night, and this declines over the years and even can dip during Menstrual Cycles, They studied melatonin levels in women and how they relate to the aging process, This finding indicates that lower levels of melatonin are a trigger for menopause.
Melatonin and cancer
Different studies have found that people there with certain cancers such as breast cancer, prostate cancer. Lung cancer, kidney cancer, liver cancer species, a low melatonin mirror, melatonin shows marked ability to modulate estrogen receptor expression and inhibit breast cancer cell growtThe administration of oral melatonin improves the effectiveness of other therapies, When properly administered, melatonin has general stimulatory effects on immune system functions; its positive anti cancer effects may stem from this strengthening of the immune response, Free radicals, especially the hydroxyl radical, can be extremely damaging to cells, Melatonin functions to destroy cancer in multiple ways  decrease in melatonin causes increased nighttime sympathetic activity, which in turn appears to increase the risk for coronary disease, Studies have also revealed melatonin to be more effective for treating pancreatic and lung cancers, Melatonin has been shown to inhibit growth of different tumors, Few people realize that melatonin is a cancer killing hormone that can enhance the human immune system, melatonin in the bone marrow has led to new views on its role in a stronger immune system.
Melatonin references
• Wolden-Hanson, Mitton, McCants, Daily melatonin administration.
• Tan, Manchester, L. C. Significance and application of melatonin.
• Reiter, R; Herman, Melatonin and radioprotection from genetic damage.
• Kunz, D; Bes,Exogenous melatonin in periodic limb movement disorder.
• Brent Bauer, M.D.. "Melatonin side effects.
• Zhdanova, I. V. Melatonin Treatment for Age-Related Insomnia.
• Morera, AL; Henry, M; De La Varga, M Safety in melatonin use.
• Arendt, Josephine; Skene, Debra Jean Melatonin as a chronobiotic.
• The infertility drug?". Melatonin, What Doctors Don't Tell You.
• Gagnier, JJ (2001). "The therapeutic potential of melatonin.
• Mills, Edward; Wu, Ping. Melatonin in the treatment of cancer. 
• Wolden-Hanson, Mitton, McCants, Daily melatonin administration. 
• Ohtani-Kaneko, Hara, Suzuki Identification of melatonin in plants.

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